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In vitro to in vivo extrapolation (IVIVE). Abbreviations: CLH, hepatic clearance; CLint, intrinsic clearance; CLint,invitro, in vitro intrinsic clearance; CLint,invivo, in vivo intrinsic clearance; fu,B, fraction unbound in blood; IVIVE, in vitro to in vivo extrapolation; kinc,u, unbound rate of incubational drug loss; QH, hepatic blood flow; Vinc, volume of in vitro incubation.
