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In vitro determinations of intrinsic clearance and high throughput assay considerations. Abbreviations: CLint,invitro, in vitro intrinsic clearance; fu,inc, fraction unbound in the incubation; kinc, rate of incubational drug loss, Km, Michaelis–Menten dissociation constant; Vinc, volume of in vitro incubation; Vmax, maximal rate of enzymatic reaction velocity.
