Table 3.
Overview of first set HBM4EU priority substance groups covered in joint HBM4EU survey.
| Substance group | Proposed analytes – included in QA/QC programme of HBM4EU | Age group | Sampled matrix | Country included in joint HBM4EU survey |
|---|---|---|---|---|
| Organophosphorus flame retardants | DPHP, BDCIPP, BCEP, BCIPP | children | urine | NO, DK, SK, Sl, FR, BE, DE |
| Brominated flame retardants | BDE-209, TBBPA, DBDPE, 2,4,6-TBP, BDE-47, BDE-153, DP-syn, DP-anti, α-HBCD, γ-HBCD | children | serum, plasma | NO, Sl, EL, FR |
| Phthalates | MEP, MBzP, MiBP, MnBP, MCHP, MnPeP, MEHP, 5OH-MEHP, 5oxo-MEHP, 5cx-MEPP, MnOP, OH-MiNP, cx-MiNP, OH-MiDP, cx-MiDP | children | urine | NO, DK, HU, SK*,PL, Sl, EL, IT, FR, DE*, NL, BE |
| teenagers | NO, SE, SK,PL, CZ, Sl, EL, ES, FR, DE*, BE | |||
| Hexamoll® DINCH | OH-MINCH, cx-MINCH | children | urine | NO, DK, HU, SK,PL, Sl, EL, IT, FR, DE*, NL, BE |
| teenagers | NO, SE, SK,PL, Sl, EL, ES, FR, DE*, BE | |||
| Per-/polyfluorinated compounds | PFPeA, PFHxA, PFHpA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, PFBS, PFHxS, PFHpS, PFOS (sum of all isomers) | teenagers | serum, plasma | NO, SE*, SK, Sl, EL, ES, FR*, DE, BE |
| Cadmium | Cd | adults | urine | DK, IS, PL, CZ, HR, PT, FR*, DE, LU |
| Polyaromatic hydrocarbons | 1-naphthol, 2-naphthol, 1,2 DHN, 2-FLUO, 3-FLUO, 9-FLUO, 1-PHEN, 2-PHEN, 3-PHEN, 4-PHEN, 9-PHEN, 1-PYR, 3-BaP | adults | urine | DK, IS, PL, CZ, HR, PT, FR*, CH, DE, LU |
| Bisphenols | BPA, BPS, BPF | adults | urine | DK, IS, FI, PL, CZ, HR, PT, FR*, CH, LU, DE |
* studies with data generated outside HBM4EU project i.e. PCB cohort (phthalates), ESTEBAN (PFAS in teenagers and PAH, bisphenols and cadmium in adults), Riksmaten Adolescents 2016–17 (PFAS), GerES V (phthalates and DINCH in children and teenagers, PFAS in teenagers). QA/QC = Quality assurance/Quality control, DK = Denmark, FI = Finland, SE = Sweden, IS = Iceland, NO = Norway, BE = Belgium, NL = The Netherlands, FR = France, DE = Germany, CH = Switzerland, LU = Luxembourg, HR = Croatia, EL = Greece, IT = Italy, PT = Portugal, Sl = Slovenia, ES = Spain, CZ = Czech Republic, PL = Poland, SK = Slovakia, HU = Hungary; MEP = Mono-ethyl phthalate, MBzP = Mono-benzyl phthalate, MiBP = Mono-isobutyl phthalate, MnBP = Mono-n-butyl phthalate, MCHP = Mono-cyclo-hexyl phthalate, MnPeP = Mono-n-pentyl phthalate, MEHP = Mono(2-ethylhexyl) phthalate, 5OH-MEHP = Mono(2-ethyl-5-hydroxyhexyl) phthalate, 5oxo-MEHP = Mono(2-ethyl-5-oxo-hexyl) phthalate, 5cx-MEPP = Mono(2-ethyl-5-carboxypentyl) phthalate, MnOP = Mono-n-octyl phthalate, OH-MiNP = 7-OH-(Mono-methyl-octyl) phthalate, cx-MiNP = 7-Carboxy-(mono-methylheptyl) phthalate, OH-MiDP = 6-OH-Mono-propyl-heptyl phthalate, cx-MiDP = Mono(2,7-methyl-7- carboxy-heptyl) phthalate, OH-MINCH = cyclohexane-1,2- dicarboxylate-mono-(7- hydroxy-4-methyl)octyl ester, cx-MINCH = cyclohexane-1,2- dicarboxylate-mono-(7- carboxylate-4- methyl)heptyl ester, DPHP = Diphenyl phosphate, BDCIPP = Bis(1,3-dichloro-2-propyl) phosphate, BCEP = Bis(2-chloroethyl) phosphate, BCIPP = bis(1-chloro-2-propyl) phosphate, BDE-209 = Polybrominated diphenylether 209, TBBPA = Tetrabromobisphenol A, DBDPE = Decabromodiphenylethane, 2,4,6-TBP = 2,4,6-Tribromophenol, BDE-47 = Polybrominated diphenylether 47, BDE-153 = Polybrominated diphenylether 153, DP-syn = Syn-dechlorane plus, DP-anti = Anti-dechlorane plus, α-HBCD = Hexabromocyclododecane alpha, γ-HBCD = Hexabromocyclododecane gamma, PFPeA = Perfluoropentanoic acid, PFHxA = Perfluorohexanoix acid, PFHpA = Perfluoroheptanoic acid, PFOA = Perfluorooctanoic acid, PFNA = Perfluorononanoic acid, PFDA = Perfluorodecanoic acid, PFUnDA = Perfluoroundecanoic acid, PFDoDA = Perfluorododecanoic acid, PFBS = Perfluorobutane sulfonic acid, PFHxS = Perfluorohexane sulfonic acid, PFHpS = Perfluoroheptane sulfonic acid, PFOS = Perfluorooctane sulfonic acid (sum of all isomers), cd = cadmium, BPA = Bisphenol A, BPS = Bisphenol S, BPF = Bisphenol F, 1-naphthol = 1-hydroxynaphthalene, 2-naphthol = 2-hydroxynaphthalene, 1,2 DHN = 1-,2-dihydroxynaphthalene, 2-FLUO = 2-hydroxyfluorene, 3-FLUO = 3-hydroxyfluorene, 9-FLUO = 9-hydroxyfluorene, 1-PHEN = 1-hydroxyphenanthrene, 2-PHEN = 2-hydroxyphenanthrene, 3-PHEN = 3-hydroxyphenanthrene, 4-PHEN = 4-hydroxyphenanthrene, 9-PHEN = 9- hydroxyphenanthrene, 1-PYR = 1-hydroxypyrene, 3-BaP = Benzo[a]pyrene.