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Knockdown of WHSC1 attenuated LPS-induced pyroptosis. (a) The protein levels of NLRP3, ASC, caspase-1 p20, IL-18, IL-1β, GSDMD FL and GSDMD CL in alveolar macrophages of mice introduced into Ad-shWHSC1 and treated with 10 mg/kg LPS were detected using Western blot. (b) The activity of caspase-1 in the alveolar macrophage of mice introduced into Ad-shWHSC1 and treated with 10 mg/kg LPS was determined. Ns: P > 0.05.
