Table 2.

Mean change in weight and other outcomes between baseline and 12-week follow-up in the overall sample (n = 55).

	Baseline		12-week		Paired t test		Generalised estimating equations
	Mean	SD	Mean	SD	Mean change	p value a	β	95% CI Lower	95% CI Upper	p value b
Weight (kg)	84.48	14.65	84.27	15.34	-0.21	0.508	−0.21	−0.41	0.84	0.501
BMI (kg/m2)	31.23	4.21	31.26	4.54	−0.03	0.814	0.03	−0.23	0.30	0.812
Waist circumference (cm)	102.47	10.11	102.65	11.00	0.19	0.744	0.19	−0.91	1.28	0.741
Metabolic parameters
Fasting glucose (mmol/L)	5.16	0.96	5.21	1.21	0.05	0.625	0.05	−0.14	0.23	0.620
HbA1c (%)	5.63	0.66	5.60	0.75	−0.03	0.509	−0.03	−0.10	0.05	0.502
Cholesterol (mmol/L)	4.88	0.97	4.60	0.94	−0.28	0.002	−0.28	−0.44	−0.11	0.001
HDL (mmol/L)	1.19	0.30	1.23	0.30	0.03	0.070	0.03	0.00	0.06	0.062
LDL (mmol/L)	2.83	0.78	2.65	0.78	−0.16	0.051	−0.17	−0.33	−0.01	0.038
Triglycerides (mmol/L)	2.07	1.34	1.79	1.16	−0.28	0.007	−0.28	−0.47	−0.08	0.005
Neurocognition tests
Symbol coding test	44.40	10.98	45.80	11.90	1.40	0.136	1.40	−0.40	3.20	0.127
Digit span	16.89	4.07	16.69	3.40	−0.20	0.552	−0.20	−0.85	0.45	0.545
Clinical scales
GAF total	67.87	8.73	72.91	8.31	5.04	<0.001	5.04	2.93	7.14	<0.001
CGI-S	2.24	0.77	2.02	0.73	-0.22	0.022	−0.22	−0.40	−0.04	0.017
CGI-I	2.15	0.80	2.35	1.11	0.17	0.290	0.15	−0.14	0.44	0.300
PANSS total	48.53	9.26	49.36	11.20	0.84	0.484	0.84	−1.47	3.14	0.477
WHODAS	20.35	7.13	20.61	8.24	0.27	0.535	0.45	−1.34	2.25	0.621

β: beta coefficient; CI: confidence interval; BMI: body mass index; HbA1c: haemoglobin A1c; HDL: high-density lipoprotein; LDL: low-density lipoprotein; GAF: Global Assessment of Functioning; CGI-S: Clinical Global Impression–Severity; CGI-I: Clinical Global Impression–Improvement; PANSS: Positive and Negative Syndrome Scale; WHODAS: World Health Organization Disability Assessment Scale.

^aPaired t test.

^bAge, sex, dosage and baseline measurements as covariates.

Bold values denote statistical significance at the p < 0.05