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. 2021 Oct 8;9(10):e002836. doi: 10.1136/jitc-2021-002836

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Subgroup analysis of PD-L1/TIM3 and PD-L1/TIGIT. Coexpression of mRNA PD-L1/TIM3 (upper panel) or PD-L1/TIGIT (bottom panel) was associated with poor OS of patients with ESCC younger than 60 years (A), males (B), or TNM stage III/IV (C) in the training cohort. The impact of protein PD-L1/TIM3 (upper panel) or PD-L1/TIGIT (bottom panel) on OS of patients with ESCC younger than 60 years (D), males (E), or TNM stage III/IV (F) in the validation cohort. ESCC, esophageal squamous cell carcinoma; OS, overall survival; PD-L1, programmed cell death 1 ligand 1; TIGIT; T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain; TIM3, T-cell immunoglobulin and mucin-domain-containing-3; TNM, primary tumor, regional lymph node, distant metastasis.