Figure 2.

Kaplan-Meier curve of intracranial progression free survival and overall survival of first-line versus second/third line ipilimumab–nivolumab. Panel A: intracranial progression-free survival (PFS). Median intracranial PFS for first-line ipilimumab–nivolumab was 41.6 months and second/third line was 1.3 months. Intracranial first-line versus second/third line ipilimumab-nivolumab PFS Mantel Cox test χ² 21.0 hazard ratio (HR)=0.208, p<0.001. Panel B: overall survival of first-line and second/third line from time of initiation of ipilimumab–nivolumab. Median overall survival for first-line and second/third line ipilimumab-nivolumab was not reached and 4.6 months, respectively. One-year and 2-year survival of first ipilimumab–nivolumab was 76.0% and 72.0%, respectively. One-year and 2-year survival of second/third line ipilimumab–nivolumab was 27.6% and 24.1%, respectively.