Figure 1.

Structure of single-ring inhibitors of α-synuclein (α-syn) aggregation.

In blue, catechol and catecholamine inhibitors norepinephrine (A), epinephrine (B), dopamine (C), entacapone (D), pyrogallol (E), hydroxytyrosol (F), and hydroquinone (G). In pink, phenolic acids, protocatechuic (H), ferulic (I), gallic (J), and caffeic (K) prevent α-syn amyloid aggregation. In gray, other phenolic structures as safranal (L), 576755 (M), and thymoquinone (N) with the capacity to inhibit α-syn aggregation. Non-phenolic inhibitors scyllo-inositol (O), selegiline (P), and ZPDm (Q) in yellow.