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. 2021 Aug 4;17(3):690–696. doi: 10.4103/1673-5374.320989

Figure 3.

Figure 3

OTX2 increases RGC survival in vivo after ONC.

Brn3A labeled RGCs of retinal flat mounts in normal adult mouse retina (A), 14 days after ONC in the retina treated with vehicle (B) and 14 days after ONC with intraocular 30 ng OTX2 (C). The images show many fewer Brn3a-labeled RGCs 14 days after ONC (B). There appears to be more labeled RGCs when treated with OTX2 14 days after ONC (C). Scale bars: 100 µm. OTX2 increased the number of RGCs by about 60% (D). *P < 0.05, Student’s t-test. n = 14 or 15 mice per treatment. ONC: Optic nerve crush; RGC: retinal ganglion cells.