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. 2021 Aug 4;17(3):690–696. doi: 10.4103/1673-5374.320989

Figure 4.

Figure 4

OTX2 increases GAP-43-labeled regenerating axons in the optic nerve 14 days after ONC.

Optic nerve (A) showing the crush site (red asterisk) and reprenstative images of regenerating axons labeled for GAP-43 (red arrows) at proximal (B) and distal (C) positions. (D) The numbers of GAP-43-positive regenerating axons along the optic nerve 14 days after ONC proximal and distal to the crush site. Starting at 1.5 mm from the ONC site, there were significantly more regenerating RGC axons in mice treated with OTX2 (30–205 ng) compared to those treated with vehicle. *P < 0.05, one-tailed Student’s t-test. n = 5–14 per time point per group. Scale bar: 250 µm. GAP-43: Growth associated protein-43; ONC: optic nerve crush; RGC: retinal ganglion cell.