Fig. 7 |. Model and summary of findings.

Left: mSWI/SNF Polycomb eviction models–nucleosome dynamics (top), DNA translocation and nucleosome sliding (middle) and direct ATP-dependent eviction (bottom). mSWI/SNF repression model: mSWI/SNF evicts Polycomb, through mechanisms described on the left, enabling accumulation at heavily occupied broad domains like Hox clusters, promoting distal repression. Within these repressed domains, BAF is weakly bound at gene promoters, supporting another level of repression. When mSWI/SNF is rapidly degraded, PRC complexes accumulate, causing redistribution away from heavily occupied sites. This leads to PRC redistribution, physical decompaction of the genome, accumulation of active marks and derepression.