Comparison 1. Drug‐eluting balloon (DEB) versus uncoated balloon angioplasty at six months.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Amputation	7	541	Odds Ratio (M‐H, Fixed, 95% CI)	1.21 [0.39, 3.80]
2 Primary vessel patency	2	162	Odds Ratio (M‐H, Random, 95% CI)	1.47 [0.22, 9.57]
3 Late lumen loss	7	603	Mean Difference (IV, Random, 95% CI)	‐0.64 [‐1.00, ‐0.28]
4 Target lesion revascularization	7	603	Odds Ratio (M‐H, Fixed, 95% CI)	0.28 [0.17, 0.47]
5 Binary restenosis	6	528	Odds Ratio (M‐H, Fixed, 95% CI)	0.44 [0.29, 0.67]
6 Death	7	541	Odds Ratio (M‐H, Fixed, 95% CI)	0.81 [0.31, 2.14]
7 Change in Rutherford category	3	249	Mean Difference (IV, Fixed, 95% CI)	‐0.07 [‐0.49, 0.36]
8 Change in ankle‐brachial index	4	369	Mean Difference (IV, Random, 95% CI)	‐0.00 [‐0.19, 0.18]
9 Change in quality of life (EQ‐5D)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
10 Change in walking impairment score	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
11 Amputation (sensitivity analysis)	4	322	Odds Ratio (M‐H, Fixed, 95% CI)	1.77 [0.42, 7.54]
12 Primary vessel patency (sensitivity analysis)	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
13 Late lumen loss (sensitivity analysis)	4	343	Mean Difference (IV, Random, 95% CI)	‐0.96 [‐1.21, ‐0.71]
14 Target lesion revascularization (sensitivity analysis)	4	343	Odds Ratio (M‐H, Fixed, 95% CI)	0.22 [0.11, 0.44]
15 Binary restenosis (sensitivity analysis)	3	268	Odds Ratio (M‐H, Fixed, 95% CI)	0.25 [0.13, 0.50]
16 Death (sensitivity analysis)	4	322	Odds Ratio (M‐H, Fixed, 95% CI)	0.57 [0.15, 2.11]
17 Change in Rutherford category (sensitivity analysis)	2	177	Mean Difference (IV, Fixed, 95% CI)	0.04 [‐0.42, 0.50]
18 Change in ankle‐brachial index (sensitivity analysis)	2	177	Mean Difference (IV, Fixed, 95% CI)	‐0.01 [‐0.09, 0.08]