Comparison 2. Drug‐eluting balloon (DEB) versus uncoated balloon angioplasty at twelve months.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Amputation	9	1649	Odds Ratio (M‐H, Fixed, 95% CI)	1.56 [0.73, 3.33]
2 Amputation‐free survival	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
3 Primary vessel patency	3	882	Odds Ratio (M‐H, Fixed, 95% CI)	1.92 [1.45, 2.56]
4 Late lumen loss	3	535	Mean Difference (IV, Random, 95% CI)	‐0.73 [‐1.59, 0.13]
5 Target lesion revascularization	11	1900	Odds Ratio (M‐H, Fixed, 95% CI)	0.40 [0.31, 0.51]
6 Binary restenosis	4	1094	Odds Ratio (M‐H, Random, 95% CI)	0.38 [0.15, 0.98]
7 Death	9	1649	Odds Ratio (M‐H, Fixed, 95% CI)	1.04 [0.64, 1.71]
8 Change in Rutherford category	3	623	Mean Difference (IV, Fixed, 95% CI)	‐0.10 [‐0.29, 0.10]
9 Change in ankle‐brachial index	3	656	Mean Difference (IV, Fixed, 95% CI)	‐0.03 [‐0.07, 0.01]
10 Change in Quality of Life (EQ‐5D)	3	879	Mean Difference (IV, Fixed, 95% CI)	0.01 [‐0.02, 0.04]
11 Change in walking impairment score	2	551	Mean Difference (IV, Fixed, 95% CI)	3.57 [‐1.23, 8.38]
12 Amputation (sensitivity analysis)	7	1517	Odds Ratio (M‐H, Fixed, 95% CI)	1.78 [0.79, 4.04]
13 Target lesion revascularization (sensitivity analysis)	8	1640	Odds Ratio (M‐H, Random, 95% CI)	0.33 [0.18, 0.61]
14 Death (sensitivity analysis)	7	1517	Odds Ratio (M‐H, Fixed, 95% CI)	1.09 [0.64, 1.85]
15 Late lumen loss (sensitivity analysis)	2	177	Mean Difference (IV, Fixed, 95% CI)	‐1.10 [‐1.41, ‐0.79]
16 Change in Rutherford category (sensitivity analysis)	2	551	Mean Difference (IV, Random, 95% CI)	0.09 [‐0.58, 0.77]
17 Change in ankle‐brachial index (sensitivity analysis)	2	551	Mean Difference (IV, Fixed, 95% CI)	‐0.01 [‐0.05, 0.03]
18 Change in quality of life (EQ‐5D) (sensitivity analysis)	2	807	Mean Difference (IV, Fixed, 95% CI)	0.02 [‐0.01, 0.05]