Comparison 3. Drug‐eluting balloon (DEB) versus uncoated balloon angioplasty at two years.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Amputation	3	493	Odds Ratio (M‐H, Fixed, 95% CI)	0.65 [0.11, 3.88]
2 Primary vessel patency	2	406	Odds Ratio (M‐H, Fixed, 95% CI)	3.51 [2.26, 5.46]
3 Late lumen loss	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
4 Target lesion revascularization	3	508	Odds Ratio (M‐H, Fixed, 95% CI)	0.28 [0.18, 0.44]
5 Binary restenosis	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
6 Death	4	595	Odds Ratio (M‐H, Fixed, 95% CI)	2.13 [1.08, 4.20]
7 Change in Rutherford category	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
8 Change in ankle‐brachial index	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
9 Change in quality of life (EQ‐5D)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
10 Change in walking impairment score	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
11 Amputation (sensitivity analysis)	2	406	Odds Ratio (M‐H, Fixed, 95% CI)	3.16 [0.12, 80.19]
12 Death (sensitivity analysis)	3	508	Odds Ratio (M‐H, Fixed, 95% CI)	2.16 [1.00, 4.67]