Comparison 5. Drug‐eluting balloon (DEB) versus uncoated balloon angioplasty at six months: arterial segment subgroup analysis.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Amputation	6		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 Femoropopliteal lesions	5	415	Odds Ratio (M‐H, Fixed, 95% CI)	1.87 [0.40, 8.75]
1.2 Tibial lesions	1	72	Odds Ratio (M‐H, Fixed, 95% CI)	1.0 [0.06, 16.63]
2 Late lumen loss	6		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 Femoropopliteal lesions	5	423	Mean Difference (IV, Fixed, 95% CI)	‐0.65 [‐0.86, ‐0.45]
2.2 Tibial lesions	1	105	Mean Difference (IV, Fixed, 95% CI)	0.02 [‐0.23, 0.27]
3 Target lesion revascularization	6		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 Femoropopliteal lesions	5	423	Odds Ratio (M‐H, Fixed, 95% CI)	0.22 [0.12, 0.41]
3.2 Tibial lesions	1	105	Odds Ratio (M‐H, Fixed, 95% CI)	0.91 [0.26, 3.18]
4 Binary restenosis	5		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 Femoropopliteal lesions	4	348	Odds Ratio (M‐H, Fixed, 95% CI)	0.26 [0.15, 0.46]
4.2 Tibial lesions	1	105	Odds Ratio (M‐H, Fixed, 95% CI)	1.85 [0.78, 4.39]
5 Death	6		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 Femoropopliteal lesions	5	415	Odds Ratio (M‐H, Fixed, 95% CI)	0.66 [0.22, 1.97]
5.2 Tibial lesions	1	72	Odds Ratio (M‐H, Fixed, 95% CI)	2.06 [0.18, 23.77]
6 Change in Rutherford category	3		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
6.1 Femoropopliteal lesions	2	177	Mean Difference (IV, Fixed, 95% CI)	0.04 [‐0.42, 0.50]
6.2 Tibial lesions	1	72	Mean Difference (IV, Fixed, 95% CI)	‐0.60 [‐1.64, 0.44]
7 Change in ankle‐brachial index	4		Mean Difference (IV, Random, 95% CI)	Subtotals only
7.1 Femoropopliteal lesions	3	264	Mean Difference (IV, Random, 95% CI)	0.07 [‐0.09, 0.22]
7.2 Tibial lesions	1	105	Mean Difference (IV, Random, 95% CI)	‐0.2 [‐0.31, ‐0.09]
8 Amputation (sensitivity analysis)	3		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
8.1 Femoropopliteal lesions	3	268	Odds Ratio (M‐H, Fixed, 95% CI)	4.47 [0.49, 40.67]
9 Late lumen loss (sensitivity analysis)	3		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
9.1 Femoropopliteal lesions	3	268	Mean Difference (IV, Fixed, 95% CI)	‐0.92 [‐1.27, ‐0.57]
10 Target lesion revascularization (sensitivity analysis)	3		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
10.1 Femoropopliteal lesions	3	268	Odds Ratio (M‐H, Fixed, 95% CI)	0.23 [0.11, 0.48]
11 Binary restenosis (sensitivity analysis)	2		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
11.1 Femoropopliteal lesions	2	193	Odds Ratio (M‐H, Fixed, 95% CI)	0.26 [0.12, 0.57]
12 Death (sensitivity analysis)	3		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
12.1 Femoropopliteal lesions	3	268	Odds Ratio (M‐H, Fixed, 95% CI)	0.57 [0.15, 2.11]
13 Change in ankle‐brachial index (sensitivity analysis)	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
13.1 Femoropopliteal lesions	2	177	Mean Difference (IV, Fixed, 95% CI)	‐0.01 [‐0.09, 0.08]