Comparison 6. Drug‐eluting balloon (DEB) versus uncoated balloon angioplasty at twelve months: arterial segment subgroup analysis.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Amputation	8		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 Femoropopliteal lesions	5	1033	Odds Ratio (M‐H, Fixed, 95% CI)	2.21 [0.23, 21.51]
1.2 Tibial lesions	3	562	Odds Ratio (M‐H, Fixed, 95% CI)	1.95 [0.78, 4.89]
2 Late lumen loss	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.1 Femoropopliteal lesions	1	102	Mean Difference (IV, Random, 95% CI)	‐1.2 [‐1.86, ‐0.54]
2.2 Tibial lesions	1	358	Mean Difference (IV, Random, 95% CI)	‐0.01 [‐0.18, 0.16]
3 Target lesion revascularization	10		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Femoropopliteal lesions	7	1230	Odds Ratio (M‐H, Random, 95% CI)	0.26 [0.13, 0.56]
3.2 Tibial lesions	3	595	Odds Ratio (M‐H, Random, 95% CI)	0.65 [0.30, 1.44]
4 Binary restenosis	4		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 Femoropopliteal lesions	2	578	Odds Ratio (M‐H, Random, 95% CI)	0.37 [0.11, 1.26]
4.2 Tibial lesions	2	516	Odds Ratio (M‐H, Random, 95% CI)	0.40 [0.05, 3.14]
5 Death	8		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 Femoropopliteal lesions	5	1033	Odds Ratio (M‐H, Fixed, 95% CI)	0.67 [0.31, 1.46]
5.2 Tibial lesions	3	562	Odds Ratio (M‐H, Fixed, 95% CI)	1.41 [0.73, 2.74]
6 Change in Rutherford category	3		Mean Difference (IV, Random, 95% CI)	Subtotals only
6.1 Femoropopliteal lesions	2	551	Mean Difference (IV, Random, 95% CI)	0.09 [‐0.58, 0.77]
6.2 Tibial lesions	1	72	Mean Difference (IV, Random, 95% CI)	0.60 [‐0.46, 1.66]
7 Change in ankle‐brachial index	3		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
7.1 Femoropopliteal lesions	2	551	Mean Difference (IV, Fixed, 95% CI)	‐0.01 [‐0.05, 0.03]
7.2 Tibial lesions	1	105	Mean Difference (IV, Fixed, 95% CI)	‐0.2 [‐0.31, ‐0.09]
8 Change in quality of life (EQ‐5D)	3		Mean Difference (IV, Random, 95% CI)	Subtotals only
8.1 Femoropopliteal lesions	2	807	Mean Difference (IV, Random, 95% CI)	0.02 [‐0.01, 0.05]
8.2 Tibial lesions	1	72	Mean Difference (IV, Random, 95% CI)	‐0.10 [‐0.22, 0.02]
9 Amputation (sensitivity analysis)	6		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
9.1 Femoropopliteal lesions	4	973	Odds Ratio (M‐H, Fixed, 95% CI)	2.21 [0.23, 21.51]
9.2 Tibial lesions	2	490	Odds Ratio (M‐H, Fixed, 95% CI)	2.10 [0.79, 5.59]
10 Target lesion revascularization (sensitivity analysis)	7		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
10.1 Femoropopliteal lesions	5	1075	Odds Ratio (M‐H, Random, 95% CI)	0.28 [0.10, 0.73]
10.2 Tibial lesions	2	490	Odds Ratio (M‐H, Random, 95% CI)	0.52 [0.18, 1.52]
11 Death (sensitivity analysis)	6		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
11.1 Femoropopliteal lesions	4	973	Odds Ratio (M‐H, Fixed, 95% CI)	0.77 [0.34, 1.73]
11.2 Tibial lesions	2	490	Odds Ratio (M‐H, Fixed, 95% CI)	1.40 [0.69, 2.83]