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. 2021 Sep 27;11:646584. doi: 10.3389/fonc.2021.646584

Table 1.

Dose restriction on organs at risk.

OARs Priority level Desirable dose MAC
Brain stem 1 D0.03ccPRV 54 Gy ≤60 Gy
Optic chiasma 1 D0.03ccPRV 54 Gy ≤60 Gy
Optic nerves 1 D0.03ccPRV 54 Gy ≤60 Gy
Spinal cord 1 D0.03ccPRV 45 Gy ≤50 Gy
Temporal lobes 2 T1-2: D0.03ccPRV 65 Gy /
T3-4: D0.03ccPRV 70 Gy ≤72 Gy
Lenses 3 D0.03cc ≤ 6 Gy D0.03cc ≤ 15 Gy
Eyes 3 Dmean ≤ 35 Gy D0.03cc ≤ 50 Gy
Pituitary gland 3 D0.03cc ≤ 60 Gy D0.03cc ≤ 65 Gy
Parotid glands 4 Dmean ≤ 26 Gy V30<50% (at least one side)
Mandible 4 D2 ≤ 70 Gy ≤75 Gy
TMJs 4 D2 ≤ 70 Gy ≤75 Gy
Inner ears 4 Dmean ≤ 45 Gy ≤55 Gy
Oral cavity 4 Dmean ≤ 40 Gy ≤50 Gy
Thyroid gland 4 V50 ≤ 60% V60 ≤ 10cm3

OARs, organs at risk; MAC, maximum acceptance criteria; TMJs, temporal-mandibular joints, PRV, planning target volume; D0.03cc, an approximate maximum dose for the organs at risk; Dmean, the mean dose of the organs at risk; D50, dose received by 50% of the volume; D2, dose received by 2% of the volume; V50, the volume of which received 50 Gy; V60, the volume of which received 60 Gy.