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. 2021 Oct 11;78(16):1635–1654. doi: 10.1016/j.jacc.2021.08.021

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© 2021 by the American College of Cardiology Foundation. Published by Elsevier.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Ongoing Statin Therapy RCTs in Patients With COVID-19

Statin trials are evaluating patients in different settings. ∗See full list of inclusion/exclusion criteria in the original trial records. ^†Enrollment setting includes hospitalized and post-discharge. AEs = adverse events; CK = creatine kinase; CrCl = creatinine clearance; CRP = C-reactive protein; CT = computed tomography; DC = discharge; DDI = drug–drug interaction; FRAIL = Fatigue Resistance, Ambulation, Illnesses, and Loss of weight questionnaire; GFR = glomerular filtration rate; HBV = hepatitis B virus; HCV = hepatitis C virus; LFT = liver function tests; MI = myocardial ischemia; NP = not pointed; P/F ratio = arterial oxygen partial pressure/fractional inspired oxygen; PDE5 = phosphodiesterase type 5; SOC = standard of care; RCTs = randomized controlled trials; C-19-ACS = Preventing cardiac complications of COVID-19 disease with early acute coronary syndrome therapy: a randomized controlled trial; COLSTAT = Colchicine/Statins for the prevention of COVID-19 complications; RESIST = A randomized control trial of statin and aspirin as adjuvant therapy in patients with SARS-CoV-2 infection; STATCO19 = Atorvastatin as adjuvant therapy in COVID-19. All other full study names are provided in the text.

Ongoing Statin Therapy RCTs in Patients With COVID-19

Statin trials are evaluating patients in different settings. ∗See full list of inclusion/exclusion criteria in the original trial records. ^†Enrollment setting includes hospitalized and post-discharge. AEs = adverse events; CK = creatine kinase; CrCl = creatinine clearance; CRP = C-reactive protein; CT = computed tomography; DC = discharge; DDI = drug–drug interaction; FRAIL = Fatigue Resistance, Ambulation, Illnesses, and Loss of weight questionnaire; GFR = glomerular filtration rate; HBV = hepatitis B virus; HCV = hepatitis C virus; LFT = liver function tests; MI = myocardial ischemia; NP = not pointed; P/F ratio = arterial oxygen partial pressure/fractional inspired oxygen; PDE5 = phosphodiesterase type 5; SOC = standard of care; RCTs = randomized controlled trials; C-19-ACS = Preventing cardiac complications of COVID-19 disease with early acute coronary syndrome therapy: a randomized controlled trial; COLSTAT = Colchicine/Statins for the prevention of COVID-19 complications; RESIST = A randomized control trial of statin and aspirin as adjuvant therapy in patients with SARS-CoV-2 infection; STATCO19 = Atorvastatin as adjuvant therapy in COVID-19. All other full study names are provided in the text.