FIGURE 4.

CREB was activated in PDGF‐BB‐exposed dopaminergic neuronal cells. PDGF‐BB‐induced time‐dependent activation of CREB expression in lysates from (A) primary dopaminergic neurons and (B) SH‐SY5Y cells. (C) Representative images of p‐CREB staining and (D) its relative intensity in SH‐SY5Y cells. Scale bars: 10 µm (E) Western blotting demonstrated that inhibitor of Akt and ERK pathways in SH‐SY5Y cells dampened PDGF‐BB‐mediated activation of CREB in the presence of MPP⁺ in SH‐SY5Y cells. All data are presented as mean ± SD of at least three individual experiments. *p < 0.05, **p < 0.01, ***p < 0.001 vs. control group, #p < 0.05, ##p < 0.01 vs. PDGF‐BB‐treated group