FIGURE 5.

Effect of CGRP on the peak distribution of the ChIP‐seq reads of H3K9ac in astroglial cells treated with CGRP compared with control. (A) Metagenes representation of average enrichment profiles of H3K9ac in astroglial cells treated with CGRP and control. The y axis represents the numbers of the total sites that were identified as H3K9ac peaks. (B) The distribution of CGRP‐mediated H3K9ac peaks relative to annotated genes in astroglial cells treated with CGRP and control. (C) The distribution of H3K9ac enrichment peaks on promoters relative to gene transcription start sites (TSSs). Shown is H3K9ac peak frequencies relative to the distance from the nearest annotated TSS in astroglial cells treated with CGRP and control. (D, E) GO annotation of genes gaining H3K9ac (D) and genes losing this mark (E) of CGRP treatment group versus control. Bar plots show the top 10 enrichment values of the significant enrichment terms involving biological process (BP). (F) KEGG pathway analysis of genes gaining H3K9ac in astroglial cells treatment with CGRP. The bar plots show enrichment values of the significant enrichment terms involving KEGG pathways