FIGURE 1.

Characters of pain persisting mice and pain recovery mice induced by plantar incision surgery. (A) and (B) The PWT and PWL of mice are tested at baseline, 1, 3, 5, 7, 10 and 14 days after incision surgery (n = 5 in each group, ****p < 0.0001, between Naive mice and Pain persisting mice; ##p < 0.01, ###p < 0.001, ####p < 0.0001, between pain persisting mice and pain recovery mice, two‐way repeated measures ANOVA followed by the Bonferroni post hoc test). (C) Photographs of plantar incision of pain persisting and pain recovery mice at different time points. (D) Representative HE staining images of the skin around the plantar incision in different pain states mice