Table 3.
- Frequency of Maternal SSRI Use During Pre-conception and/or Pregnancy among Women with Any Psychiatric Disorder, Study to Explore Early Development, 2002–2006 and 2008–2011 Births.
| SSRI Usea | ASD | DD | POP | ASD vs POP | DD vs POP |
|---|---|---|---|---|---|
|
| |||||
| n (%b) | n (%b) | n (%b) | p-value | p-value | |
|
| |||||
| Any Psychiatric Condition | 128 (25.6) | 167 (28.2) | 94 (20.7) | 0.07 | 0.005 |
| ADHD | 10 (19.2) | 12 (20.0) | 4 (13.3) | 0.49 | 0.44 |
| Anxiety Disorder | 83 (38.1) | 118 (42.9) | 46 (27.1) | 0.02 | 0.001 |
| Bipolar Disorder | 16 (32.7) | 26 (40.6) | 14 (42.4) | 0.37 | 0.86 |
| Depression | 118 (31.7) | 147 (35.2) | 88 (27.4) | 0.22 | 0.02 |
| Eating Disorder | 11 (31.4) | 10 (22.7) | 5 (11.1) | 0.02 | 0.14 |
| OCD | 8 (34.8) | 9 (28.1) | 4 (28.6) | 0.70 | 0.98 |
| Personality Disorder | 1 (11.1) | 7 (50.0) | 1 (16.6) | 1.00 | 0.32 |
| Schizophrenia | 2 (40.0) | 6 (85.7) | 0 (0.0) | 1.00 | 0.08 |
| Sleep Disorder | 25 (22.9) | 30 (25.9) | 11 (16.2) | 0.28 | 0.13 |
| Self-Injuring Behavior | 9 (42.9) | 6 (30.0) | 4 (19.0) | 0.18 | 0.41 |
| Suicide Attempt | 14 (28.6) | 20 (33.3) | 8 (29.6) | 0.92 | 0.73 |
ADHD=Attention-deficit/hyperactivity disorder; ASD=Autism spectrum disorder; DD=Developmental disorder; n=Number; OCD=Obsessive-compulsive disorder; POP=Population controls; SSRI=Selective serotonin reuptake inhibitor
Use of antidepressants and diagnoses of psychiatric conditions were independently assessed. The psychiatric condition listed in the table may not be the indication for the mother’s SSRI treatment. This table excludes 9 mothers who used SSRIs during pregnancy but did not have a reported/documented psychiatric condition (4 in DD and 5 in POP).
The proportion of women with each specific psychiatric condition who used SSRIs during pregnancy. The denominators for each psychiatric condition are listed in Table 2.