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Histopathological evaluation of rat livers 12 h after the administration of RSV in combination with CP (H&E staining, ×200). The liver sections (A) Single i.v. dose RSV + Multiple p.o. dose CP (Group I); (B) Single i.v. dose RSV + Multiple p.o. dose vehicle control (Group II); (C) Single p.o. dose RSV + Multiple p.o. dose CP (Group Ⅲ); (D) Single p.o. dose RSV + Multiple p.o. dose vehicle control (Group Ⅳ). p.o. dose: p.o. administration as oral gavage.
