TABLE 2.
Liver function index | Group I single i.v. dose RSV + multiple p.o. dose CP | Group II single i.v. dose RSV + multiple p.o. dose vehicle control | Group Ⅲ single p.o. dose RSV + multiple p.o. dose CP | Group Ⅳ single p.o. dose RSV + multiple p.o. dose vehicle control |
---|---|---|---|---|
ALT (U/L) | 46.50 ± 11.27 | 54.00 ± 14.17 | 54.50 ± 18.43 | 52.00 ± 6.68 |
AST (U/L) | 169.75 ± 17.93 | 210.50 ± 36.59 | 196.00 ± 36.28 | 212.50 ± 33.72 |
TBIL (μmol/L) | 1.95 ± 0.44 | 2.00 ± 0.22 | 2.00 ± 0.49* | 1.13 ± 0.42 |
DBIL (μmol/L) | 0.89 ± 0.42 | 1.12 ± 0.11 | 1.16 ± 0.17* | 0.58 ± 0.33 |
IBIL (μmol/L) | 1.06 ± 0.21 | 0.88 ± 0.18 | 0.85 ± 0.33 | 0.57 ± 0.36 |
p.o. dose: p.o. administration as oral gavage.