Fig. 1. Workflow of data analysis. MCF10A, MDA-MB-231, and HCC1937 cells were cultured and DNA, RNA, and protein were extracted for DNA methylation, RNAseq, protein expression, and analysis of phosphorylated peptides and histone post-translational modifications. Each single omics data set was individually analyzed. The feature annotations were then curated to match between each omics type and were integrated using correlation analysis, MixOmics, and MOGSA to find significant features of TNBC.
