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Exemplary topologies of the P-loop (a) and Rossman folds (b). Both folds belong to the α/β class. Whereas the P-loop containing nucleoside triphosphate hydrolases (SCOPe classification: c.37) have a 5- or 6-stranded β-sheet in the order 23145(6), the NAD(P)-binding Rossmann fold (c.2) has a 6-stranded β-sheet with the order 321456
