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Mechanisms of Resistance
| On Target Resistance Mechanisms | Off Target Resistance Mechanisms |
|---|---|
| Clinical findings | |
| G12D | BRAF mutations |
| G12R | BRAF fusions |
| G12V | MEK |
| G12W | MAP2K1 |
| G13D | NRAS |
| Q61H | ALK |
| R68S | RET |
| H95D | FGFR3 |
| H95Q | RAF1 |
| H95R | |
| Y96C | |
| In vitro findings | |
| Y96D | MEK |
| Y96S | |
| G13D | |
| R68M | |
| A59S | |
| A59T |
