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. 2021 Sep 27;13:717644. doi: 10.3389/fnagi.2021.717644

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Copyright © 2021 Liu, Zheng, Xu, Cao, Wang, Wang, Zhao, Zhang and Liao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enriched environment improved long-term neurobehavioral function of MCAO/R rats. (A) The mNSS of ISC and IEE group. Rats were tested before MCAO surgery. (B) The escape latency in the spatial learning phase. (C,D) Time in the correct quadrant and the crossovers in the target quadrant was recorded and analyzed. (E) Representative swimming trajectories of SSC, SEE, ISC, and IEE group in the probe trials. n = 12. Data are expressed as mean ± SD. *p < 0.05 vs. SSC group; ^##p < 0.01,^###p < 0.001 vs. ISC group.