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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Microcirculation. 2021 Apr 8;28(5):e12687. doi: 10.1111/micc.12687

Figure 9.

Figure 9.

Extension of vascular synthesis methodology from the mouse to the human brain. The iCNS algorithm was applied to a human cortical surface reconstruction for growing a network of the main cerebral arteries including the Circle of Willis, the MCA, PCA, and ACA reaching down to the level of the distal pial vessels. This result shows that the same principles of synthesis and staged growth used in the mouse hemisphere was successful in producing fully-closed vascular structures for the human brain.