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. 2021 Sep 27;9:740702. doi: 10.3389/fchem.2021.740702

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Copyright © 2021 Xiong, Xiang, Huang, Liu, Wang, Ge, Chen, Xu, Zheng and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-SARS-CoV-2-S pseudovirus activities and cytotoxicities of several compounds. (A) Determining Anti-SARS-CoV-2-S pseudovirus activities of 24 compounds showing the potent blocking activities against SARS-CoV-2 S-RBD/ACE2 interaction in the initial NanoBiT assay using the two concentrations (10, 100 μM); (B-F) IC₅₀ and CC₅₀ values of five compounds: (B) DC-RA016, (C) DC-RA052, (D) DC-RA076, (E) DC-RA087, (F) DC-RA106; Relative Luminescence (%) standing for the infection of SARS-CoV-2-S pseudovirus (blue), cell viability (purple).