Fig 1. Concept of the preclinical proton minibeam irradiation facility.

A 16 MeV proton beam provided by a tandem is accelerated to 70 MeV by a radio-frequency linac system and subsequently focused to 0.1 x 0.1 mm² by a quadrupole triplet. The 6-dimensional phase space of the tandem beam is matched to the accepted phase space of the linac by a buncher unit and a quadrupole quartet.