. 2021 Jun 25;14(5):1689–1704. doi: 10.1111/cts.13061

TABLE 4.

Changes in the virtual population for RI ^a

	Control (normal renal function)		Moderate RI (GFR 30 – 59 ml/min/1.73 m²)		Severe RI (GFR <30 ml/min/1.73 m²)	Women
	Males	Females	Males	Females	Males	Women
Albumin (g/l)	50.3	49.4	41.0	39.8	37.0	31.2
Hematocrit (%)	43	38	37.8	36.4	32.9	31.3
Gastric emptying time (h)	0.4		0.55		0.65
Extrapolated CYP abundance (pmol/mg protein)
CYP1A2	52		28.4		27.4
CYP2C8	24		20		13
CYP2C9	73		63		29
CYP2C19	14		5.5		2.3
CYP2D6	8.0		4.6		2.1
CYP3A4	137		95.2		87.3

Abbreviations: GFR, glomerular filtration rate; RI, renal impairment.

Note: All the CYP abundances is referring to the EM group.

^{^a}

These include mean values used in the Simcyp population‐based simulator (Certara UK division) as described by Rowland et al. ⁵⁴ as well as parameters reported by Sayama et al. ⁵⁵