TABLE 1.
Plasma PK parameters (arithmetic mean ± SD) of GDC‐0334 following single oral administration in rats, dogs, and monkeys
|
Species n = 3/group |
Tmax (h) | Cmax (ng/ml) | AUC0–24 h (ng•hr/ml) |
Oral % (F) |
|---|---|---|---|---|
| Rat (5 mg/kg) | 6.00 ± 3.46 | 568 ± 85.9 | 9140 ± 1410 | 80.8 ± 12.7 |
| Dog (1 mg/kg) | 0.417 ± 0.144 | 291 ± 65.8 | 2030 ± 563 | 68.7 ± 19.0 |
| Monkey (1 mg/kg) | 0.833 ± 0.289 | 270 ± 47.5 | 849 ± 191 | 85.0 ± 20.0 |
The vehicle was DMSO (dimethyl sulfoxide)/0.5% methylcellulose with 0.2% polysorbate 80 (Tween 80) in water (15:85).
Abbreviations: AUC0–24 h, area under the concentration‐time curve from 0 to 24 h; Cmax, maximum concentration observed; F, bioavailability; PK, pharmacokinetic; SD, standard deviation; Tmax, time to maximum concentration.