Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Biological implications and potential mechanisms of mild interferonopathy in DS. Interferons have pleiotropic effects on multiple organs and different effects on different cell types. IFN can drive T-cell activation and differentiation which is considered to be the third signal for T-cell development, in addition to the TCR and the costimulatory receptor. The tissue and temporal effects of interferonopathy in DS remain to be explored.
Abbreviation: APC, antigen-presenting cells.
