Figure 2.

Multivariate PLSC analysis between the NVC pattern alteration and clinical blood biochemistry tests in ESRD patients. Multivariate PLSC analysis correlating the NVC pattern alteration to clinical blood biochemistry tests revealed one significant LV (p < 0.05) which accounted for 38.16% of the cross-block covariance. The pattern identified by the LV showed that the lower fALFF-CBF coefficients in the CG (section (a)) were positively associated with lower Kt/V values, and were negatively associated with higher serum urea (section (b)).

PLSC: partial least-squares correlation; NVC: neurovascular coupling; fALFF: fractional amplitude of low-frequency fluctuation; CBF: cerebral blood flow; LV: latent variable; CG: cingulate gyrus; Kt/V: kinetic transfer/volume urea; ESRD: end-stage renal disease.