Figure 3.

Multivariate PLSC analysis between the NVC pattern’s alteration and cognitive variables in ESRD patients. Multivariate PLSC analysis correlating the NVC pattern’s alteration to cognitive variables revealed one significant LV (p < 0.05), which accounted for 46.70% of the cross-block covariance. The pattern identified by the LV showed that lower fALFF-CBF coefficients in the CG (section (a)) were positively associated with lower SR-S values (section (b)).

PLSC: partial least-squares correlation; NVC: neurovascular coupling; fALFF: fractional amplitude of low-frequency fluctuation; CBF: cerebral blood flow; CG: cingulate gyrus; LV: latent variable; SR-S: short-term delayed recall score; ESRD: end-stage renal disease.