Figure 5.
Ichise's multilinear analysis (MA1)-derived parametric images for [11C]clozapine ([11C]CLZ) and [11C]deschloroclozapine ([11C]DCZ). Parameters were determined from baseline and blockade scans (clozapine-N-oxide (CNO) 10 mg/kg i.v.). Four distribution volumes are displayed and corrected for free fraction in plasma (fP): VND, nondisplaceable distribution volume; VS, specific distribution volume (i.e., all displaceable binding); VS-off, off-target distribution volume; and VS-on, on-target distribution volume. The modified binding potential BPND′ is the ratio of VS-on to VND.