Correia 2012.

Trial name or title	Resin infiltration on the sealing of proximal early caries lesions: a randomised trial
Methods	Split‐mouth randomised controlled trial No funding statement Drop‐out 0% after 12 months
Participants	9 participants (56% female, 44% male), aged 5‐40 years, with ≥ 2 lesions up to the enamel‐dentinal junction. Total of 26 lesions. Exclusion criteria: pregnancy, history of tumours of salivary glands, lesions without adjacent tooth, ongoing orthodontic treatment
Interventions	Two treatment arms: Group 1: resin infiltration (Icon, DMG) + fluoride varnish application + oral hygiene and dietary advice Group 2: fluoride varnish application + oral hygiene and dietary advice For group 1, resin infiltration was performed according to manufacturer's instructions. In addition, fluoride varnish, dietary advice and oral hygiene instruction were provided. Group 2 received non‐invasive treatments only.
Outcomes	Lesion progression according to pairwise reading and digital subtraction radiography
Starting date	NA
Contact information	Marisa Maltz, Odontologia Preventiva e Social. Porto Alegre, Universidade Federal do Rio Grande do Sul, marisa.maltz@gmail.com
Notes	At 12 months, 2/13 infiltrated and 1/13 non‐invasively treated lesions progressed according to pairwise reading. DSR found 3/13 and 0/13 lesions to progress, respectively.