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. 2016 May 13;2016(5):CD011801. doi: 10.1002/14651858.CD011801.pub2

Comparison 1. Adults: higher dose/longer course vs lower dose/shorter course.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Re‐admission during follow‐up period 4   Odds Ratio (M‐H, Random, 95% CI) Subtotals only
1.1 Longer vs shorter course prednisolone 4 142 Odds Ratio (M‐H, Random, 95% CI) 1.35 [0.38, 4.79]
2 Asthma symptoms: asthma severity score 1   Mean Difference (IV, Random, 95% CI) Totals not selected
2.1 Longer vs shorter course prednisolone 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
3 Asthma symptoms: complete resolution 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
3.1 Longer vs shorter course prednisolone 1   Odds Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
4 New exacerbation during follow‐up period: requiring visit to healthcare provider 4   Risk Difference (M‐H, Random, 95% CI) Subtotals only
4.1 Longer vs shorter course prednisolone 2 55 Risk Difference (M‐H, Random, 95% CI) ‐0.00 [‐0.14, 0.14]
4.2 Stable vs tapered prednisolone 2 41 Risk Difference (M‐H, Random, 95% CI) 0.09 [‐0.07, 0.26]
5 New exacerbation during follow‐up period: oral corticosteroids prescribed 3 122 Odds Ratio (M‐H, Random, 95% CI) 0.62 [0.23, 1.68]
5.1 Longer vs shorter course prednisolone 3 122 Odds Ratio (M‐H, Random, 95% CI) 0.62 [0.23, 1.68]
6 Lung function tests: trough PEFR 2   Mean Difference (IV, Random, 95% CI) Subtotals only
6.1 Longer vs shorter prednisolone (trough PEFR) 2 79 Mean Difference (IV, Random, 95% CI) ‐4.81 [‐45.82, 36.20]
7 Lung function tests: FEV1% predicted 2   Mean Difference (IV, Random, 95% CI) Subtotals only
7.1 Stable vs tapered prednisolone (FEV1% predicted) 2 41 Mean Difference (IV, Random, 95% CI) ‐1.02 [‐4.62, 2.58]
8 Lung function tests: number of participants achieving personal best at 4 weeks 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
8.1 Longer vs shorter course prednisolone 1   Odds Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
9 All adverse events 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
9.1 Longer vs shorter course prednisolone 1   Odds Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]