Clinical manifestation of infection	IDSA Infection severity	PEDIS grade
Wound without purulence or any manifestation of inflammation	Uninfected	1
Two or more manifestations of inflammation (purulence or erythema, pain, tenderness, warmth or induration); any cellulitis or erythema extends up to 2 cm around ulcer, and infection is limited to skin or superficial subcutaneous tissues; no local complications or systemic illness	Mild	2
Infection in a patient who is systemically well and metabolically stable but has one or more of the following: cellulitis extending for more than 2 cm; lymphangitis; spread beneath fascia; deep tissue abscess; gangrene; muscle, tendon, joint or bone involvement	Moderate	3
Infection in a patient with systemic toxicity or metabolic instability (e.g. fever, chills, tachycardia, hypotension, confusion, vomiting, leukocytosis, acidosis, hyperglycaemia or azotaemia)	Severe	4