| Study | Reason for exclusion |
|---|---|
| Acevedo 1990 | Not an RCT |
| Akova 1996 | Not an RCT |
| Al‐Ebous 2005 | Data for participants with DFI unavailable |
| Beam 1989 | Not an RCT |
| Bradsher 1984 | Data for participants with DFI unavailable for the main outcome (clinical evaluation). |
| Cenizal 2007 | People with DFIs excluded |
| Chantelau 1996 | The study did not evaluate any of the systematic review's main outcomes |
| Chen 2013 | Review assessed for locating RCT |
| Crouzet 2011 | Review assessed for locating RCT |
| Daniel 1999 | Data for participants with DFI unavailable |
| Darwish 1993 | The study did not evaluate systemic antibiotics |
| Deresinski 2008 | The study described 2 trials, one included in the review, and the other did not fill the inclusion criteria |
| Edmonds 2004 | Review assessed for locating RCT |
| Embil 2006 | Data for participants with DFI unavailable |
| Fernández Montequín 1991 | Study with participants post‐amputation |
| File 1983 | Data for participants with DFI unavailable |
| File 1994 | Review assessed for locating RCT |
| Foster 1998 | The study was in people with foot ulcers but no infection |
| Gentry 1989a | Data for participants with DFI unavailable |
| Gentry 1989b | Data for participants with DFI unavailable |
| Hughes 1987 | Data for participants with DFI unavailable |
| Itani 2010 | Data for participants with DFI unavailable |
| Joshi 2003 | Not an RCT |
| Lipksy 2011 | Review assessed for locating RCT |
| Lipsky 1999a | Data for participants with DFI unavailable |
| Nelson 2006b | Review assessed for locating RCT |
| Noel 2008b | Data for participants with DFI unavailable |
| Peters 2012 | Review assessed for locating RCT |
| Peterson 1989 | Data for participants with DFI unavailable |
| Pérez‐Ruvalcaba 1987 | Data for participants with DFI unavailable |
| Siami 2002 | Data for participants with DFI unavailable |
| Siebert 1985 | Only 2 participants with DFI and both treated with the same antimicrobial |
| Smith 1992 | The abstract was published approximately 20 years ago; it contained no usable data and appears not to have been published in full subsequently |
| Smith 1993 | Data for participants with DFI unavailable |
| Stevens 1999 | Data for participants with DFI unavailable |
| Stevens 2000 | People with diabetic foot ulcer excluded |
| Stevens 2002 | People with diabetic foot ulcer excluded |
| Stupin 2014 | Open clinical trial without randomisation |
| Vardakas 2008 | Review assessed for locating RCT |
| Weigelt 2005 | Data for participants with DFI unavailable |
Abbreviations
DFI: diabetic foot infection RCT: randomised controlled trial