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. 2021 Oct 4;2021:9970272. doi: 10.1155/2021/9970272

Figure 1.

Figure 1

circAMOTL1L is downregulated in RCC tissues and cells and correlates with poor prognosis. (a) Hematoxylin and eosin staining of RCC tissues and adjacent noncancerous tissues. (b) qRT-PCR examined circAMOTL1L expression in 51 paired RCC tissues and adjacent noncancerous tissues. Normalized to GAPDH. ∗∗p < 0.01 vs. normal adjacent noncancerous tissues. (c) The circAMOTL1L expression levels in RCC tissues with different tumor sizes. ∗∗p < 0.01 vs. tumor sizes < 7 cm. (d) circAMOTL1L expression in patients with RCC with or without metastasis. ∗∗p < 0.01 vs. no metastasis. (e) Kaplan–Meier analysis of the overall survival of patients with RCC having high and low expression of circAMOTL1L. ∗p < 0.05. (f) qRT-PCR examined circAMOTL1L expression in the human renal tubular epithelial cell line HK-2 and five RCC cell lines. ∗p < 0.05, ∗∗p < 0.01 vs. HK2 cells. Graph bars represent mean ± SEM of three independent experiments.