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. 2021 Oct 4;2021:9970272. doi: 10.1155/2021/9970272

Figure 4.

Figure 4

miR-92a-2-5p mediates the regulation of circAMOTL1L in the proliferation and apoptosis of RCC cells. (a) qRT-PCR examined miR-92a-2-5p expression in 786-O cells transfected with the miR-92a-2-5p mimic, anti-miR-92a-2-5p, or its corresponding control miR. ∗∗∗p < 0.001 vs. Ctl mimic; ##p < 0.01 vs. anti-miR-Ctl. (b) CCK-8 assay examined the proliferation of 786-O cells after transfection with pcDNA-circAMOTL1L or miR-92a-2-5p mimic or cotransfection with both. ∗p < 0.05 vs. control group; #p < 0.05 vs. pcDNA-circAMOTL1L group. (c) CCK-8 assay examined cell proliferation in 786-O cells after transfection with pcDNA-circAMOTL1L or anti-miR-92a-2-5p or cotransfection with both. ∗p < 0.05 vs. control group; #p < 0.05 vs. pcDNA-circAMOTL1L group. (d, e) TUNEL assay detected cell apoptosis in 786-O cells treated as (b) and (c), respectively. ∗p < 0.05, ∗∗p < 0.01 vs. control group; #p < 0.05, ##p < 0.01 vs. pcDNA-circAMOTL1L group (scale bars = 50 μm). Graph bars represent mean ± SEM of three independent experiments.