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. 2021 Oct 4;2021:1703981. doi: 10.1155/2021/1703981

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Copyright © 2021 Xiwen Geng et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Treatment with Jie-Yu-He-Huan capsule prevents alterations in the 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations caused by chronic restraint stress. (a) 5-HT level in the prefrontal cortex (PFC). (b) 5-HIAA level in the PFC. (c) 5-HT/5-HIAA ratio in the PFC. (d) 5-HT level in the hippocampus. (e) 5-HIAA level in the hippocampus. (f) 5-HT/5-HIAA ratio in the hippocampus. ^∗p < 0.05 compared to the control group, ^∗∗p < 0.01 compared to the control group, and ^#p < 0.05 compared to the model group (unpaired t-test). Data are expressed as the means ± SEs. The small circles represent individual data points.