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. 2021 Oct 4;2021:1703981. doi: 10.1155/2021/1703981

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Copyright © 2021 Xiwen Geng et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Schematic of the possible mechanism underlying the anxiolytic effect of the Jie-Yu-He-Huan capsule. The Chinese medicine formula Jie-Yu-He-Huan can ameliorate anxiety-like behaviours in rats exposed to chronic restraint stress by normalising the overactivated HPA axis function, ultimately regulating the 5-HT system, and finally targeting the cAMP-PKA-CREB-BDNF signalling pathway. HPA: hypothalamic–pituitary–adrenal; JYHH: Jie-Yu-He-Huan capsule; CRS: chronic restraint stress; CRH: corticotropin-releasing hormone; ACTH: adrenocorticotropic hormone; GR: glucocorticoid receptor; CORT: corticosterone; PFC: prefrontal cortex; 5-HT: 5-hydroxytryptamine; 5-HT1AR: 5-HT1A receptor; cAMP: cyclic adenosine monophosphate; PKA: protein kinase A; CREB: cAMP response element-binding protein; BDNF: brain-derived neurotrophic factor.