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. 2021 Oct 4;2021:5712280. doi: 10.1155/2021/5712280

Figure 3.

Figure 3

circFAM160A2 acts as a sponge of miR-505-3p. (a) The expression of hsa_circ_0020990, hsa_circ_0075423, and hsa_circ_0084161 was detected using qRT-PCR both in human OA cartilage and control cartilage tissue (N = 6). (b) The binding sites of miR-505-3p and circFAM160A2. (c) HEK-293T cells were transfected with miR-505-3p or NC and luciferase reporter constructs containing wt or mut circFAM160A2. (d) The chondrocytes were treated with or without lentivirus-circFAM160A2, lentivirus-miR-505-3p, or lentivirus vector, respectively. The levels of SIRT3 and GAPDH were detected using WB (N = 3) (data are presented as the mean ± SD, ∗P < 0.05 vs. control or as indicated by Student's t-test).