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. 2021 Oct 4;2021:5712280. doi: 10.1155/2021/5712280

Figure 5.

Figure 5

circFAM160A2 alleviates OA in vivo. (a) ACLT-induced OA mice were injected with AAV negative control, wt AAV circFAM160A2, or mut AAV circFAM160A2. The relative expression of miR-505-3p was detected using qRT-PCR (N = 3). (b, c) The relative expression of SIRT3, procaspase 3, Bax, MMP13, COL2, and GAPDH was detected using WB (N = 3). (d) Typical images of Safranin O/fast green staining of the cartilage in the indicated groups at six weeks after surgery (data are presented as the mean ± SD, ∗P < 0.05 vs. control, #P < 0.05 vs. ACLT group by Student's t-test).