Table 1.

RAS receptor distribution change in response to hypertension. AT₁R distribution change related to time after 2K1C or 2K1W in hypertensive rat models.

Major RAS receptors		Hypertension
AT1 receptor		Aorta AT1R expression Vascular and glomerular AT1R downregulation Proximal tubular receptors upregulation or not significantly altered
AT1 receptor alteration after 2K1C or 2K1W in hypertensive rat models		Time after clipping
	1 week	AT1R mRNA in the clipped, wrapped, and contralateral kidneys
	10 days	AT1AR protein in clipped and unclipped kidneys
	2 weeks	Glomerular AT1R
	10 weeks	AT1R mRNA levels in clipped and unclipped kidneys
	16 weeks	Vascular AT1R
AT2 receptor		Aorta AT2R expression unchanged Sodium depletion & SHR AT2R expression AT2R downregulation only in clipped and wrapped kidneys, in 2K1C and 2K1W
Mas receptor		Carotid MasR protein expression in 2K1C rats MasR in proximal tubules of clipped kidney in male rats MasR in clipped and unclipped kidney of female rats