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The method of calculation of osteolytic lesions in Osteolytica. (a) Original volume of the sample. (b) Reconstruction of the surface of the sample and filling lesions, diffusing the volumetric surface outwards. (c) The volume of the osteolytic lesions measured through the subtraction of the original surface from the reconstructed one. The expanded volume will diffuse inwards through a variable over the surface [84].
