Fig. 1.

Kaplan-Meier curves of overall survival from the date of cystectomy over a 40-yr period for (A) metastatic and nonmetastatic patients and (B) metastatic and nonmetastatic patients stratified by pathologic subgroup stages of organ confined (OC), extravesical (EV), and node positive (N+). Probability curves of developing metastatic disease after cystectomy of primary BCa over time for (C) all patients and (D) patients stratified by pathologic subgroup stage. For the probability of developing metastatic disease for all patients (Fig. 1C), data points (black) are calculated as the number of metastatic patients who have not progressed yet divided by the total number of patients who are still at risk of progression. The probabilities are subsequently fit to an exponential decay function (red). An identical approach is taken for groups stratified by pathologic subgroup stage (Fig. 1D). BCa = bladder cancer.